This site is intended for US Healthcare Professionals

Easy to prescribe

Starting patients with Demodex blepharitis on XDEMVY is as easy as 1‑2‑3

Include the following key information on the Rx:

QUANTITY: 10-mL fill in an 11-mL container1

DOSAGE: Instill 1 drop in each eye twice daily (approximately 12 hours apart) for 6 weeks1

DIAGNOSIS: Indicate Demodex blepharitis and provide the appropriate ICD-10 codes (see tables below)

REFILLS: Consider adding a refill in case symptoms return

XDEMVY® (lotilaner ophthalmic solution) 0.25%

DISP: 10 mL

SIG: Instill 1 drop in each eye twice daily, 12 hours apart, for 6 weeks

Dx: Demodex blepharitis (B88 + H01)

REFILLS: 1

Key reminders:

  • Over time, Demodex blepharitis may reoccur after initial treatment2
  • A Tarsus-sponsored survey* found that ECPs routinely add a refill for XDEMVY to support timely retreatment when needed3

Survey Design: Based on a cross-sectional survey of 100 US ECPs (optometrists [n=53] and ophthalmologists [n=47]) assessing clinicians’ decision-making related to retreatment of Demodex blepharitis with XDEMVY. Retreatment was defined as an additional course of therapy after completing the initial full regimen (6-week course/full bottle of XDEMVY). 54 out of 100 ECPs reported prescribing XDEMVY with refills.

Indicate Demodex blepharitis and provide the appropriate ICD‑10 codes4

B88 CODE
B88.01
Infestation by Demodex mites

New as of October 1, 2025

Key reminders:

  • Consider using the most specific diagnosis code possible†
  • Use the notes section to add the second code if only one ICD-10 code is permitted
AT LEAST ONE H01 CODE
H01.001
Unspecified blepharitis
right upper eyelid
H01.004
Unspecified blepharitis
left upper eyelid
H01.002
Unspecified blepharitis
right lower eyelid
H01.005
Unspecified blepharitis
left lower eyelid
H01.003
Unspecified blepharitis
right eye, unspecified eyelid
H01.006
Unspecified blepharitis unspecified eye,
unspecified eyelid
H01.00A
Unspecified blepharitis right eye,
upper and lower eyelids
H01.00B
Unspecified blepharitis left eye,
upper and lower eyelids
H01.009
Unspecified blepharitis unspecified eye,
unspecified eyelid

Key reminders:

  • Consider using the most specific diagnosis code possible†
  • Use the notes section to add the second code if only one ICD-10 code is permitted

It is the responsibility of the healthcare provider to clinically diagnose each patient, verify the available codes, and select the codes that accurately reflect each patient’s diagnosis. The information on this page is for informational purposes only and should not be interpreted as a guarantee of coverage or payment. Contact payers directly for the latest coverage and claims guidance. For current information on ICD-10 codes, please refer to an ICD-10-CM resource. All information is subject to change.

ICD-10-CM=International Classification of Diseases, 10th Revision, Clinical Modification.

†For guidance on how to use the new codes, see https://www.aoa.org/news/practice-management/billing-and-coding/new-demodex-blepharitis-codes-available-for-optometrists.

Prescribe XDEMVY to an authorized pharmacy that is activated to assist

BlinkRx
Phone: 1-833-919-4942
Fax: 1-866-585-4631
12639 W Explorer Dr, Suite 100
Boise, ID 83713
NPI #: 1891461885
Carepoint Pharmacy
Phone: 1-855-237-9112
Fax: 1-855-237-9113
9 E. Commerce Drive
Schaumburg, IL 60173
NPI #: 1598013864
CenterWell Specialty Pharmacy
Phone: 1-800-486-2668
Fax: 1-877-405-7940
9843 Windisch Rd
West Chester, OH 45069
NPI #: 1942441886
CVS Specialty Pharmacy (2 locations)
Phone: 1-800-237-2767
Fax: 1-800-323-2445
800 Biermann Court Suite B
Mount Prospect, IL 60056
NPI #: 1134100134
105 Mall Boulevard
Monroeville, PA 15146
NPI #: 1043382302
Walgreens Specialty Pharmacy
Phone: 1-800-424-9002
Fax: 1-800-874-9179
41460 Haggerty Circle South
Canton, MI 48188
NPI #: 1942303110
Walmart Specialty Pharmacy
Phone: 1-877-453-4566
Fax: 1-866-537-0877
2354 Commerce Park Dr,
Orlando, FL 32819
NPI #: 1013934413

OR

Locate a community pharmacy using the form below:

OR OR
See full alphabetical listing of community pharmacies

Set patient expectations

Patients should expect a text or phone call directly from the pharmacy. They should reach out to the pharmacy if they don't hear from them, so their treatment is not delayed.

Remind patients to ask the pharmacy for ways to save on XDEMVY. Patients may be required to provide personal information (eg, Social Security number) to verify their eligibility.

Let patients know when you've included a refill and that they should expect a call from the pharmacy.

Pay as little as $30 or less for XDEMVY‡

Real XDEMVY patient

‡With payer coverage and available assistance options, and based on eligibility requirements; see XDEMVY Savings and Access Terms and Conditions.

Get the info you need to send Demodex mites packing

Sign Up for Updates

Dosing

Discover the simplicity of XDEMVY

Support Materials

DB treatment is within reach

Reference: 1. XDEMVY [prescribing information]. Tarsus Pharmaceuticals, Inc; 2024. 2. Sadri E, Paauw JD, Ciolino JB, et al. Long-term outcomes of 6-week treatment of lotilaner ophthalmic solution, 0.25%, for Demodex blepharitis: a noninterventional extension study. Cornea. 2024;43(11):1368-1374. 3. Data on file, Tarsus Pharmaceuticals, Inc. 4. Centers for Medicare & Medicaid Services. 2026 ICD-10-CM: October 1, 2025 UPDATE. Accessed August 25, 2026. https://www.cms.gov/medicare/coding-billing/icd-10-codes

INDICATIONS AND USAGE
XDEMVY (lotilaner ophthalmic solution) 0.25% is indicated for the treatment of Demodex blepharitis.

IMPORTANT SAFETY INFORMATION:

WARNINGS AND PRECAUTIONS

Risk of Contamination: Do not allow the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.

Use with Contact Lenses: XDEMVY contains potassium sorbate, which may discolor soft contact lenses. Contact lenses should be removed prior to instillation of XDEMVY and may be reinserted 15 minutes following its administration.

ADVERSE REACTIONS: The most common adverse reaction with XDEMVY was instillation site stinging and burning which was reported in 10% of patients. Other ocular adverse reactions reported in less than 2% of patients were chalazion/hordeolum and punctate keratitis.

To report SUSPECTED ADVERSE REACTIONS, contact Tarsus Pharmaceuticals, Inc. at 1-888-421-4002 or the FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Please see full Prescribing Information.

Available by prescription only.

INDICATIONS AND USAGE
XDEMVY (lotilaner ophthalmic solution) 0.25% is indicated for the treatment of Demodex blepharitis.

IMPORTANT SAFETY INFORMATION:

WARNINGS AND PRECAUTIONS

Risk of Contamination: Do not allow the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.